Folate Metabolism Test 2.0
THIS TEST CAN HELP IF
- You were diagnosed with vitamin B deficiency and taking supplements doesn't help
- Your biological age is higher than your chronological age
- You constantly feel fatigued, weakness, or a general lack of energy
- You experience numbness or tingling in your hands or feet
- Your muscles feel weak and have slow reflexes
- You feel shaky when walking and have trouble keeping your balance
- You are frequently anemic
- You struggle with depression, low-mood, or 'brain-fog'
Your folate metabolism can cause these issues
Vitamin B deficiency severly disrupts folate metabolism and this imbalance quickly results in increased levels of homocysteine; a toxic metabolic compound that induces DNA damage, cellular stress, and premature biological aging.
The vitamin B complex plays an essential role in your wellbeing with a direct impact on energy levels and cellular health but is very often overlooked.
Complete daily supplements are a one-size-fits-all, blind attempt to treat deficiencies. However, studies are showing these don't work for a lot of people and can actually be harmful to your health.
TruMe offers you the opportunity to make educated and personalized decisions, based on your genetic profile, in supplement regime and lifestyle choices.
TruMe Labs Folate Metabolism Test 2.0 provides a complete genetic profile of how your body absorbs B vitamins and produces homocysteine. Take control of your wellness and make informed decisions to improve your health and reverse your biological age!
What makes it 2.0 - Folate metabolism and beyond
The B vitamins are critical building block materials for a number of cellular processes, but perhaps one of the most critical is supporting the activity of an enzyme called Catechol-O-MethyTransferase, encoded by the gene COMT. This enzyme plays an essential and key role in the breakdown of neurotransmitters, hormones, and clearing toxins from your cells. Without available B vitamins, this enzyme simply doesn't function!
However, studies have identified a genetic variant in this gene that reduces activity up to 4X, even with optimal B vitamins! Without this enzyme working properly, your body can build up of a large number of compounds and toxins and profoundly affect your health and wellbeing.
Our Folate Metabolism 2.0 test screens, not only the entire folate metabolism pathway, but also looks for this specific variant (COMT Val158Met). This variant is carried by approximately 30% of Caucasians with European ancestory, and along with a B vitamin deficiency, is a biological "double-whammy". This gene variant could very likely be the root cause for a wide variety of possible ailments.
Now here's where the science gets fun! Like most things in life, it's all a balancing act. The COMT gene is commonly described as the "worrier" gene or the "warrior" gene, depending on the specific variants a person has. And as we have two copies of our genes, the combination of the two is a critical aspect to consider!
The "worrier" variant has the most reduced activity with both copies of the COMT genes impacted. These indiviuals tend to have high levels of neurotransmitters that are responsible for cognitive functioning, well-being and emotional health, short-term memory, and stress reactions. These individuals remain in an elevated state of stress and hormones which is physically exhausting and takes a huge toll on cognative ability.
The "warrior" variant has the highest COMT enzyme activity. These individuals are able to breakdown and clear their systems of these compounds very efficiently. And although these individuals tend to respond better under stress since they more easily return to a state of calm, they can find themselves having difficulty sustaining attention and seeking out stressful or thrilling situations.
Here's the great news ~ there are a number of lifestyle and diet factors that can potentially speed up or slow down COMT enzyme activity! But in order to know precisely what you need and what you should avoid, you have to know your COMT genotype. Your genetic COMT status might be completely undoing all the efforts you've been putting into your wellness routine! Certain suppliments might be rendered completely useless or even worse harmful to your health!
With the Folate Metabolism 2.0 test, our team has expanded the markers screened in the Folate Genetics Test to include this additional marker that provides your COMT2 gene status report.
The combination of COMT status with an entire folate metabolism analysis is an incredibly powerful tool, giving you peace of mind knowing the suppliment, food, and lifestyle choices you've made are specifically designed and taylored to your unique biology.
Your folate metabolism might be the reason attempts to reverse aging have not been successful.
Approximately one-third of TruMe subscribers, after taking our TruAge Explorer Test, reaches out with an inquiry:
"Why is my TruAge higher than my chronological age? I have a very healthy lifestyle!"
In order to explain this delimma and demonstrate how critical folate metabolism can be for whole body wellness, we tested our clients' folate metabolism
"Getting a result showing I'm 10-years older was not expected, especially given that I am a non-smoker, non-drinker, and am fairly fit and active and at a healthy weight/BMI."
What was the reason?
- Results of folate genetics test showed Yao's ability to absorb vitamin B12 was compromised.
- He also had lowered folic acid levels and increased homocysteine
"I have added a few extra things to my supplements, regular Metformin and C-60 with my Rapamycin. This medication reversed my biological age from 64 to 51 years old. However, it's been about a year since I began taking them and my biological age is creeping up again. What could be causing this?"
What was wrong?
- John carries a variant that compromises absorption of vitamin B12
- Medications (Metformin) can compete with the absorption of vitamin B12
"I lost weight and normalized my BMI. I am eating healthy and following an intermediate fasting diet that is supposed to help my general health. What is the reason I am not getting younger?"
What was the reason?
Anna had lower folic acid and vitamin B6 levels due her inability to absorb it.
Even if you are taking supplements and living a healthy lifestyle, you likely aren't getting all the building blocks your body needs for optimum wellness!
TruMe Labs Folate Metabolism Test shows if your body is absorbing and using B vitamins efficiently.
TruMe Labs is dedicated to providing our subscribers with the insight and tools to develop a personalized wellness plan.
Start making informed decisions to improve your health and lifespan
- Choose supplements based on your genetics and what your body really needs
- Be the scientist of your own body and know what works (and doesn't work) for you
- Discover the potential cause for why your wellness journey isn't succeeding
- Make sure your lifestyle is truly the best options for your health and longevity
The Trume advantage - why a blood test isn't enough
A blood test from your doctor may have detected a vitamin deficiency, but that test can't identify the cause of an imbalance. Your genes are a likely reason.
Furthermore, a blood test only measures vitamin levels TODAY which are easily influenced by the foods and medications consumed up to 3 days before the test!
TruMe Folate Metabolic Test gives you complete insight to your body's ability to absorb and use B vitamins as building blocks for your wellness.
Knowing the strengths and weaknesses of your body on a genetic level is essential for achieving optimal health and longevity
How the test works
TruMe Folate Metabolic Test analyzes specific genes in your sample for *genetic variants that are known to impact folate metabolism. These genetic variants can be influencing how your body absorbs and uses B vitamins.
*A genetic variant is a naturally occuring genetic difference found in 25% or more of the population.
what the test provides
- Your folate metabolism report with identification of any detected variants and predicted tendancy for specific vitamin deficiencies
- Assessment for risk of developing chronic anemia and related complications
- Personalized tips on lifestyle changes, including foods and supplemention, for reducing genetic concerns
- Detailed information on the specific genes and B vitamins analyzed
- Scientific referrences for those who want to learn more
IT'S TIME TO RECLAIM YOUR HEALTH!!!
START ON THE REJUVINATION JOURNEY THAT FINALLY ACHIEVES YOUR WELLNESS GOALS
Have you already taken our standard Folate Metabolism test?
If you've already taken our standard Folate Metabolism test and are now looking to gain further insight into your COMT2 variation, TruMe Labs has an exclusive offer for you!
You can purchase our special bundle "Upgrade your Folate Metabolism report + TruAge Test". By bundling these tests, you can gain a more complete picture of your health and take informed steps to improve your well-being.