The B vitamins are critical building block materials for a number of cellular processes, but perhaps one of the most critical is supporting the activity of an enzyme called Catechol-O-MethyTransferase, encoded by the gene COMT. This enzyme plays an essential and key role in the breakdown of neurotransmitters, hormones, and clearing toxins from your cells. Without available B vitamins, this enzyme simply doesn't function!

However, studies have identified a genetic variant in this gene that reduces activity up to 4X, even with optimal B vitamins! Without this enzyme working properly, your body can build up of a large number of compounds and toxins and profoundly affect your health and wellbeing.

Our Folate Metabolism 2.0 test screens, not only the entire folate metabolism pathway, but also looks for this specific variant (COMT Val158Met). This variant is carried by approximately 30% of Caucasians with European ancestory, and along with a B vitamin deficiency, is a biological "double-whammy". This gene variant could very likely be the root cause for a wide variety of possible ailments.

Now here's where the science gets fun! Like most things in life, it's all a balancing act. The COMT gene is commonly described as the "worrier" gene or the "warrior" gene, depending on the specific variants a person has. And as we have two copies of our genes, the combination of the two is a critical aspect to consider!

The "worrier" variant has the most reduced activity with both copies of the COMT genes impacted. These indiviuals tend to have high levels of neurotransmitters that are responsible for cognitive functioning, well-being and emotional health, short-term memory, and stress reactions. These individuals remain in an elevated state of stress and hormones which is physically exhausting and takes a huge toll on cognative ability.

The "warrior" variant has the highest COMT enzyme activity. These individuals are able to breakdown and clear their systems of these compounds very efficiently. And although these individuals tend to respond better under stress since they more easily return to a state of calm, they can find themselves having difficulty sustaining attention and seeking out stressful or thrilling situations.

Here's the great news ~ there are a number of lifestyle and diet factors that can potentially speed up or slow down COMT enzyme activity! But in order to know precisely what you need and what you should avoid, you have to know your COMT genotype. Your genetic COMT status might be completely undoing all the efforts you've been putting into your wellness routine! Certain suppliments might be rendered completely useless or even worse harmful to your health!

With the Folate Metabolism 2.0 test, our team has expanded the markers screened in the Folate Genetics Test to include this additional marker that provides your COMT2 gene status report.

The combination of COMT status with an entire folate metabolism analysis is an incredibly powerful tool, giving you peace of mind knowing the suppliment, food, and lifestyle choices you've made are specifically designed and taylored to your unique biology.

A blood test from your doctor may have detected a vitamin deficiency, but that test can't identify the cause of an imbalance. Your genes are a likely reason.

Furthermore, a blood test only measures vitamin levels TODAY which are easily influenced by the foods and medications consumed up to 3 days before the test!

TruMe Folate Metabolic Test gives you complete insight to your body's ability to absorb and use B vitamins as building blocks for your wellness.

Knowing the strengths and weaknesses of your body on a genetic level is essential for achieving optimal health and longevity